Abstract
The first total synthesis of 15R-PGD(2)3 was accomplished. The approach used in this report is also an efficient method to produce 15R-PGE(2). 15R-PGD(2), a potential DP(2) receptor agonist, could be an important novel tool for defining the role of this receptor in inflammatory diseases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Blood Platelets / drug effects*
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Blood Platelets / metabolism
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Cyclic AMP / metabolism*
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Isomerism
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Prostaglandin D2 / analogs & derivatives*
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Prostaglandin D2 / chemical synthesis*
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Prostaglandin D2 / pharmacology
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Receptors, Immunologic / agonists*
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Receptors, Immunologic / metabolism
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Receptors, Prostaglandin / agonists*
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Receptors, Prostaglandin / metabolism
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Structure-Activity Relationship
Substances
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Receptors, Immunologic
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Receptors, Prostaglandin
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15-methylprostaglandin D2
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Cyclic AMP
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Prostaglandin D2
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prostaglandin D2 receptor